Melissa Brooks
Summary
Computational Biologist (Scientist).
Experienced scientist with a strong background in research and analysis. Proficient in experimental design, data analysis, and interpretation across various scientific disciplines. Demonstrated ability to contribute to impactful research projects and collaborate effectively with interdisciplinary teams. .
Overview
15
15
years of professional experience
Work History
Associate Computational Scientist
The Jackson Laboratory
Farmington
05.2023 - Current
- My research focuses on the comprehension of the genetic complexity of human diseases using computational graph theory and network biology and, an in-depth mining of high-throughput multiomics datasets to hunt important therapeutic targets
- I visualize diseases in a systemic perspective to confidently translate statistical observations on biological grounds
- Big datasets always excite me to figure out their fundamental implication for therapeutic benefit
Postdoctoral Researcher
TGen - an Affiliate of City of Hope
Phoenix
08.2019 - 04.2023
- Diseases/ Traits investigated: Human aging and longevity, Cancer biology and other complex disorders
- Cross-species gene interaction-based network and pathway analysis to understanding the molecular basis of human longevity using diverse computational systems biology approaches
- Workflow design using various statical tools in R and Cytoscape for personalized pathway analysis using differential gene expression data for various cancer patients
- Comparative gene-set based pathway enrichment analysis using transcriptomic data for multiple bird species
- Design functional enrichment analysis workflow for different multi-omics (cellular organoids, iPSC, scRNAseq and whole genome exome sequence) datasets
Senior Research Fellow
Bioinformatics Infrastructure Facility, Sri Venkateswara College, University of Delhi
Delhi
06.2012 - 04.2014
- Diseases/ Traits investigated: complex neurological diseases - Schizophrenia and Alzheimer's disease
- Structure modeling and molecular dynamics (MD) simulations of membrane proteins
- In slico docking study- Protein-Ligand and Protein-Protein interactions
- Mutation effect analysis on docking conformations and kinetics
- Novel drug like molecule identification through computer aided drug designing (CADD) approaches
Project Fellow
Institute of genomics and integrative biology (CSIR)
Delhi
09.2009 - 12.2011
- Diseases/ Traits investigated: type 2 diabetes, Metabolic Syndrome, cpeptide in Indian population
- Raw genotyping data handling both for Illumina and Sequnome platform
- Genome wide data analysis- Data quality control (QC) and association analysis
- Imputation technique for genome wide data
- Sequencing data analysis- Normal and bisulfate converted DNA
- In sillico annotation and functional characterization of coding and non-coding genes using various databases and software tools
Education
Doctor of Philosophy - PhD - Computational Biology
Delhi University
12.2019
M.Sc.Tech - Bioinformatics
West Bengal University of Technology, Kolkata
12.2009
B.Sc - Zoology
Calcutta University, Kolkata
12.2005
Skills
- Network Science
- Data Science
- Computational Biology
- Machine Learning
Publications
- Elevated levels of C - reactive protein as a risk factor for Metabolic Syndrome in Indians
- Data on overlapping brain disorders and emerging drug targets in human Dopamine Receptors Interaction Network
- Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21
- New Insights into Schizophrenia Disease Genes Interactome in the Human Brain: Emerging Targets and Therapeutic Implications in the Postgenomics Era.
- Design, synthesis and biological evaluation of Arylpiperazine-based novel Phthalimides: Active inducers of testicular germ cell apoptosis
Languages
English
First Language
Hindi
Advanced (C1)
C1
Timeline
Associate Computational Scientist
The Jackson Laboratory
05.2023 - Current
Postdoctoral Researcher
TGen - an Affiliate of City of Hope
08.2019 - 04.2023
Senior Research Fellow
Bioinformatics Infrastructure Facility, Sri Venkateswara College, University of Delhi
06.2012 - 04.2014
Project Fellow
Institute of genomics and integrative biology (CSIR)
09.2009 - 12.2011
Doctor of Philosophy - PhD - Computational Biology
Delhi University
M.Sc.Tech - Bioinformatics
West Bengal University of Technology, Kolkata
B.Sc - Zoology
Calcutta University, Kolkata
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