John Milton
Biophysicist & Neuroscientist
Cambridge
Summary
In-vitro Electrophysiologist with 15+ years of experience utilizing diverse electrophysiological tools to study various ion channels (K +, Na+, Ca2+, TRP, RyR, Hv, etc.) in both native and heterologous cell systems. I am a molecular and cell biologist with a robust background in biophysics, protein structure-function analysis, homology modeling, and data analysis. My experience includes mentoring junior colleagues in research projects and laboratory work. I am particularly passionate about the early stages of the drug discovery process, team management, and science outreach. Currently, I am committed to advancing innovative therapeutic solutions to transform the lives of neuropsychiatric patients through cutting-edge scientific technology.
Scientist with extensive experience in research and development. Proven ability to lead groundbreaking projects, contributing to significant scientific advancements. Known for effective team collaboration and achieving results within dynamic environments. Proficient in data analysis and experimental design.
Overview
17
17
years of professional experience
13
13
years of post-secondary education
4
4
Certifications
2
2
Languages
Work History
Senior Research Scientist
Broad Institute of MIT and Harvard
12.2024 - Current
Senior Scientist
Neumora
07.2021 - 01.2024
Research Scientist I
Broad Institute of MIT and Harvard
07.2019 - 07.2021
- Structure-function and early drug-discovery studies on ion channels genetically linked to mental disorders using automated electrophysiology and other high throughput cell-based assays
Postdoctoral Associate at Stanley Center for Psychiatric Research
Broad Institute of MIT and Harvard
10.2015 - 06.2019
- Jen Pan's lab is focused to understand the molecular and cellular mechanisms that underlie psychiatric disorders, such as schizophrenia, bipolar disorder and autism among others
- My research project was focused on the role of Cav3.3 channel (human neuronal calcium channel) and naturally-occurring variants associated to patients that suffer these diseases
- The long term goal of Pan lab is try to develop new specific treatment for these patients, combining the structure-function knowledge from our research on Cav 3.3, complemented with classical neurobiology and medicinal chemistry
Postdoctoral Researcher
CINV
03.2013 - 09.2015
- The aim of my research project was to understand the gating and permeation mechanism of voltage-gated proton channel (Hv)
- Two electrodes voltage-clamp fluorimetry - Patch-clamp (macropatches) - cloning - molecular biology
PhD student
Universidad de Valparaíso
03.2008 - 02.2013
- Research on thermo-activated ion channels (thermoTRP)
- Structure-function analysis to elucidate voltage and temperature activation in the context of allosteric model of activation
- Laser temperature clamp - Planar lipid bilayer - patch-clamp (Xenopus oocytes and primary cells) - molecular biology - biochemistry - computational modelling
Education
Doctor of Philosophy (PhD) - Neuroscience
Universidad de Valparaíso
03.2008 - 02.2013
Master of Science (MSc) - Biochemistry
Pontificia Universidad Católica de Valparaíso
01.2006 - 12.2007
Bachelor of Science (BS) - Biochemistry
Pontificia Universidad Católica de Valparaíso
01.2000 - 12.2005
Skills
- Research Projects
- Written Communication
- Project Leadership
Laboratory safety protocols
SQL databases
Presentation management
undefinedPublications
- Could an allosteric gating model explain the role of TRPA1 in cold hypersensitivity?
- Analysing an allelic series of rare missense variants of CACNA1I in a Swedish schizophrenia cohort
- Thermo-TRP channels: biophysics of polymodal receptors
- Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons
- Ion Channel Drugs Suppress Cancer Phenotype in NG108-15 and U87 Cells: Toward Novel Electroceuticals for Glioblastoma
Awards
- Biophysical Society Student Research Achievement Award SRAA
- Student Travel Award SOBLA
- Biophysical Society Travel Award
- Santander Ibero-American Grants
- Young Teachers and Researchers Biophysical Journal Outstanding Poster Award
Certification
Certified Clinical Research Associate (CCRA) - Association of Clinical Research Professionals.
Timeline
Senior Research Scientist
Broad Institute of MIT and Harvard
12.2024 - Current
Senior Scientist
Neumora
07.2021 - 01.2024
Research Scientist I
Broad Institute of MIT and Harvard
07.2019 - 07.2021
Postdoctoral Associate at Stanley Center for Psychiatric Research
Broad Institute of MIT and Harvard
10.2015 - 06.2019
Postdoctoral Researcher
CINV
03.2013 - 09.2015
PhD student
Universidad de Valparaíso
03.2008 - 02.2013
Doctor of Philosophy (PhD) - Neuroscience
Universidad de Valparaíso
03.2008 - 02.2013
Master of Science (MSc) - Biochemistry
Pontificia Universidad Católica de Valparaíso
01.2006 - 12.2007
Bachelor of Science (BS) - Biochemistry
Pontificia Universidad Católica de Valparaíso
01.2000 - 12.2005
Certified Clinical Research Associate (CCRA) - Association of Clinical Research Professionals.
Certified Forensic Examiner (CFE) - International Association of Forensic Sciences.
Professional Wetland Scientist (PWS) - Society of Wetland Scientists.
Lean Six Sigma Green Belt / Black Belt Certifications – Various Accrediting Bodies.
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